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Gout is a form of arthritis caused by the buildup of uric acid crystals in the joints of the body, causing inflammation, swelling and pain.

The normal body processing of Purine ( protein substances  that are found naturally in our diets) by the liver results in an end product called uric acid which then gets excreted by the kidneys. A build-up of uric acid occurs when the body has difficulty eliminating uric acid through the kidneys and urine, or in some cases, when the body produces too much uric acid. Dietary intake of rich foods - red meat, cream sauces, red wine and brandy can put more uric acid into the bloodstream than the kidneys can filter. When uric acid builds up in the blood, it begins to crystallize over time and settles in the joint spaces which irritates the joint lining and causes severe joint inflammation, or an acute gout attack.
 Left untreated, acute gout attacks can last for hours to weeks. The average time between the first attack and a recurrence is about 1 year unless some preventative treatment occurs. Over time, untreated gout may result in attacks that are more frequent and longer in duration. Irreversible joint damage also may occur. 

90% of gout cases are due to the underexcretion of uric acid from the kidneys. Gout occurs most commonly in the big toe or ankle joint but any joint may be involved including the knees, ankles, fingers, wrists, or elbows. Women, in particular, are likely to experience gout in the hands. Another possible result of high blood uric acid levels is the development of kidney stones. Some individuals have noted gout attacks to be triggered by trauma, alcohol, or stress.

The tendency to accumulate uric acid is often hereditary. It can, however, skip an individual or even a generation and reappear in the children of someone who has no signs of gout. While it is most commonly seen in males between fifty and sixty years of age, gout does occur in females and in younger males.
 
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